Free Download The Practice of Medicinal Chemistry

Free Download The Practice of Medicinal Chemistry

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The Practice of Medicinal Chemistry

Free Download The Practice of Medicinal Chemistry

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Review

“A useful, authoritative discussion of the principles and practice of medicinal chemistry... the volume has a useful index, is well produced and is very reasonably priced." - JOURNAL OF MEDICINAL CHEMISTRY

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About the Author

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Centre d’Etudes Physio-biologiques Appliquées à la Marine" in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine. Professor Wermuths’ main research themes focus on the chemistry and the pharmacology of pyridazine derivatives. The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists. More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF (corticotrophin-releasing factor) which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. Professor Wermuth has also, in collaboration with Professor Jean-Charles Schwartz and Doctor Pierre Sokoloff (INSERM, Paris), developed selective ligands of the newly discovered dopamine D3 receptor. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome. Dr. Wermuth is co-author or editor of several books, the author of over 250 scientific papers and holds nearly 60 patents. Professor Wermuth is also the recipient of the Charles Mentzer Prize of the Société Française de Chimie Thérapeutique, the Léon Velluz Prize of the French Academy of Science, the Prix de l'Ordre des Pharmaciens by the French Academy of Pharmacy and the Nauta Award of the European Federation for Medicinal Chemistry for Pharmacochemistry in 2010.

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Product details

Series: The Practice of Medicinal Chemistry

Hardcover: 982 pages

Publisher: Academic Press; 3 edition (August 7, 2008)

Language: English

ISBN-10: 0123741947

ISBN-13: 978-0123741943

Product Dimensions:

8.5 x 1.6 x 11 inches

Shipping Weight: 4.8 pounds (View shipping rates and policies)

Average Customer Review:

4.6 out of 5 stars

3 customer reviews

Amazon Best Sellers Rank:

#2,328,294 in Books (See Top 100 in Books)

An amazing book about medicinal chemistry!

I think this is one of the most comprehensive and user-friendly books in the Medicinal Chemistry field

It is a nice and useful book for me! I received this book around 2 weeks since it was sent, it's quick!

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Ebook Fantasy: The Literature of Subversion (New Accents)

Ebook Fantasy: The Literature of Subversion (New Accents)

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Review

`Dr Jackson has written a wide-ranging and frequently stimulating introduction to the subject of 'fantasy in modern literature.' - Times Literary Supplement

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Product details

Series: New Accents

Paperback: 224 pages

Publisher: Routledge; 1 edition (March 12, 1981)

Language: English

ISBN-10: 0748790438

ISBN-13: 978-0748790432

ASIN: 0415025621

Product Dimensions:

5.1 x 0.5 x 7.8 inches

Shipping Weight: 10.7 ounces (View shipping rates and policies)

Average Customer Review:

4.3 out of 5 stars

4 customer reviews

Amazon Best Sellers Rank:

#451,399 in Books (See Top 100 in Books)

An excellent complement to Todorov's ideas on the Fantastic. Easily written and therefore easily read, this book contains a flow of ideas to work with the fantastic and give it its denied place amongst critical literature.

It's a really good read for those seeking to understand fantastic literature at an academic level. It is very well written.

Too complex and subjective as all psychoanalytical works go, but insightful and certainly one of a kind. Had a hard time to read it through, and the term FANTASY is too broadly understood, but once again - a unique perspective of analysis for the genre anyway.

This is one of my favorite theory books, not too heavy handed and some really thoughtful work. I just loved it, espically Dr. Jackson's ideas about the Faust and Frankenstien legands. Anyone who's looking for something to start with regarding the fantasy and horror genres should really pick this one up. It's really great!

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Ebook Download , by Briallen Hopper

Ebook Download , by Briallen Hopper

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Product details

File Size: 987 KB

Print Length: 323 pages

Publisher: Bloomsbury Publishing; 1 edition (February 5, 2019)

Publication Date: February 5, 2019

Sold by: Amazon Digital Services LLC

Language: English

ASIN: B07FLDGMY3

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Amazon Best Sellers Rank:

#291,954 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

This book is already one of my "saving grace" books (like Middlemarch, Sense and Sensibility, Tiny Beautiful Things, Lit), books that hold me up when I need comfort and a loving, generous, and sharp-eyed vision of the world. Hard to Love is compulsively readable, but also critically astute—I combination I long for and don’t find that often. It gives original insights into literature, television shows and other cultural forms, even offering a new view of conventions like the “author photo,” or, quite delightfully, sperm donation profiles. It is both entertaining as a read, but also thought-provoking on a larger level, doing something bold and sweeping: it stages a cultural intervention about the way we talk about dependence and love as Americans. If women have been urged to “lean in,” this book suggests that we consider the value of leaning on and being leaned on. Hopper gives a vision of support that occurs outside of and in addition to the marriage plots of adult life. The book has impressive range and scope: it talks about alternate forms of family, about standing by sick and grieving friends, about being single and building a life of joy, about trying to have a baby on one's own (the essay, "Moby Dick" about picking a sperm donor made me tear up with laughter), about adult sibling relationships (I love the essay “Dear Octopus” about her brother), about female friendship, about hoarding and how treasured objects spark pyrotechnical-levels of joy, about loving literature and finding models of friendship and social organization in its pages. As a married 40-something woman with two kids, I can say this book isn’t just about singleness—it’s about so much more. It gives a vision of friendship that can exist at a time in life when it feels like the “fierce” loves of youth can disappear while one is being stretched too thin. These “fierce female loves,” as Hopper shows us, have potential not only to nurture us in adult life, but also to offer a social model of support that is undervalued, undermined by a prevailing culture of “individualism” and “self-reliance.” All I can say is that this book really sings to me. Hopper gives a vision of what life can be, lived well, lived with love, lived with friends, no matter what your marital status, sexual preference, or age. This book will, I think, sing to many others too who long for its urgent, loving vision. It’s my new go-to gift for friends.

I have been a fan of Briallen Hopper's work for awhile and was so excited to see her book come out. These essays are incisive, funny, and profoundly meaningful. They have helped me to think about love and friendship in new ways that I appreciate so much! (And literature and American culture and so many other things). I keep buying copies for friends because I want everyone to read this book. HIGHLY recommend!

These essays moved me to tears and made me laugh out loud. They are a vital reminder that love and intimacy can take many, many forms.

This was a neat and thoughtful collection, and while I didn't love all the essays I found them all at least interesting.The one that struck me the most was her essay on "Cheers," which I watched when I was younger but didn't have the perspective to see the human behavior in the same way. Her reflection on Ted Danson's Sam Malone as a middle-aged man beset with ennui now feels relevant in a way it certainly did not in 1983. I also agreed with her thoughts on the post-Diane season, which even young I remembered feeling uncomfortable about the portrayal of Kristie Alley's Rebecca.What I also appreciated about her essays is how "mechanical" they are - which doesn't sound like a compliment. I can see the construction and planning - you could easily use these essays in a writing class for HOW to put an essay together, and how the various ingredients all come together to support a thesis. It would obviously be difficult to 'copy' but she's giving a close reader a roadmap for how to gather their own thoughts.I like any collection that takes a writer's thoughts and validates them by connecting them to the larger world - by using various books or TV series like "Cheers," Hopper feels relevant and part of the larger world. A lot of times essays can feel totally submerged by the writer's thoughts; even if I didn't connect with some of her essays, they felt worldly to me - never self-indulgent naval-gazing.Solid collection that any reader of personal essays, and our own intersections with culture, should appreciate.

Hopper's book begins: "I like to lean. Too much of the time I must hold myself up, so if an opportunity to swoon presents itself, I take it. When I’m getting a haircut and the lady asks me to lean back into the basin for a shampoo, I let myself melt. My muscles go slack, my eyes fall shut, and there is nothing holding me except gravity and the chair and the water and her hands on my head. I feel my tears of bliss slide into the suds." What follows is a gorgeous set of essays about the art of leaning on (and being leaned on by) other people-- on sisters, friends, and the many others who help us through life. Hopper's essay "Dear Flannery," co-written with her friend Ashley Makar while Makar was facing a very serious cancer diagnosis, is one of the most beautiful pieces of writing I've read in my life. In this essay, Hopper and Makar write to each other their reflections on Flannery O'Connor's prayer journals as a way of coping with what seemed at the time to be Makar's imminent death. This essay, as well as Acquainted with Grief and Young Adult Cancer Story, reveal the practice of leaning on others at its most profound extreme, the domain in which our care for one another seems most truly like a glimpse of divine grace. In the other essays, Hopper celebrates the delights of lighter and more joyful kinds of everyday leaning, whether that be baking for her students, appreciating the friendship communities featured in classic TV shows like "Cheers" and "The Golden Girls," writing about her own sisters, or describing her experiences at the Women's March. I really loved this book-- it gave me a chance to pause and appreciate the people I have leaned on in my life, and it has inspired me to think about how I can be the kind of friend Hopper suggests we all need. I've ordered a copy for my mom which I've asked her to pass along to my sister when she's done reading it.

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Ebook Free Lonely Planet British Columbia & the Canadian Rockies (Travel Guide), by Lonely Planet

Ebook Free Lonely Planet British Columbia & the Canadian Rockies (Travel Guide), by Lonely Planet

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Lonely Planet British Columbia & the Canadian Rockies (Travel Guide), by Lonely Planet

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Product details

Series: Travel Guide

Paperback: 320 pages

Publisher: Lonely Planet; 7 edition (April 18, 2017)

Language: English

ISBN-10: 1786573377

ISBN-13: 978-1786573377

Product Dimensions:

5 x 0.7 x 7.8 inches

Shipping Weight: 12 ounces (View shipping rates and policies)

Average Customer Review:

3.7 out of 5 stars

5 customer reviews

Amazon Best Sellers Rank:

#80,513 in Books (See Top 100 in Books)

very minimal and not very thorough. the coming trip will be my 4th, and I find they have missed as much as they have touted. Is someone paying them for recommendations?

Item just as described. Therefore very helpful

Great resource

Not enough info for the areas we are traveling to. (I have bought Lonely Planet travel books before and loved them)

good

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